1. Open the Message Flow using the instance's context menu of HAT or Administration Console
2. Use the link "Show tracked Orchestration Exceptions".
This will show you an error text, which actually explains the error. :-)
Random pitfalls (and their solutions) in EAI technologies such as BizTalk

Iterate over the partyCollection and create XML documents
XmlTextWriter xmlWriter = new XmlTextWriter(@"SmallBinding.xml",Encoding.UTF8);
xmlWriter.WriteStartDocument();
xmlWriter.WriteStartElement("BindingInfo");
xmlWriter.WriteStartElement("PartyCollection");
...
Finally use BTS-Task to import the slice:
Process process = new Process();
process.StartInfo.FileName = @"C:\...\BTSTask.exe";
process.StartInfo.Arguments = "importbindings -Source:" + @"SmallBinding.xml";
process.Start();
process.WaitForExit();